Saturday, January 29, 2011

The Blinding Effects of Onchocerca volvulus

[2]

Introduction to Onchocerca volvulus:
Onchocerca volvulus is a parasitic nematode that infects humans via epidermal penetration from female black flies (Simulium), and causes the disease known as Onchocerciasis, or "River Blindness." [1] The majority of infections from O.volvulus occur in regions of West Africa; however, some cases have been discovered in sub-Sahara Africa, Mexico, Venzuela, Guatemala, and Ecuador. Although infection from O. volvulus is not fatal, reactions to this parasite can be quite unpleasant and painful.[3] These reactions include destruction of the elastic tissue and formation of redundant folds in the skin, loss of pigmentation, and in the most extreme cases, the skin of the host resembles the skin of a very old normal subject. [2] O.volvulus also causes long-term corneal inflammation, or Keratitis, and thickening of the corneal stroma, which leads to permanent blindness. [1] Onchocerciasis cannot be prevented or cured; however, available medicine can offer short-term pain relief.[4]
Description of Onchocerca volvulus:
O. volvulus is part of the family Onchocercidae in the order of Spirurida, which targets humans through transfer from its vector host, the female black fly. In its vector host, O. volvulus is usually found in the saliva within the proboscis so that when the female fly lands on a human for its "blood meal," O. volvulus can be transferred into the blood of the host. Once the parasite enters the blood of the primary host, it migrates to the subcutaneous tissue where it forms painful nodules that are visible through the skin. [1] O. volvulus can also enter the eyes of the host through the ciliary vessels and nerves under the bulbar conjunctiva into the cornea and the optic nerve; however, the major reactions of O.volvulus do not occur until after the death of the parasite. Once the parasite dies it causes an inflammatory immune response within the host and formation of secondary cataracts and ocular lesions, leading to progressive blindness. It also causes inflammation of regional lymph nodes, causing the nodes to protrude and enfold into pockets of skin. Extreme cases of this can be classified as minor elephantiasis. O. volvulus microfilariae, the beginning larval stage, measure 300 mm in length and 0.8mm in diameter, and contain sharply pointed, curved tails. [2]
[2]
[2]

Life Cycle of Onchocerca volvulus:


The life cycle of O. volvulus begins when a female black fly takes a blood meal. O. volvulus microfilariae, found in the dermis of the human host, is ingested by the female fly. The microfilariae then penetrates the gut of the fly and migrates to the thoracic flight muscles where it enters the J1 larval stage. Once the microfilariae matures into the J2 larval stage, it migrates to the proboscis of the fly and resides in the saliva. Here the O. volvulus matures into the J35 larval stage and passes from the saliva of the fly to the blood of a human through the fly's pentration of the human's epidermis. The larvae then migrates to the subcutaneous tissue, forming a nodule that matures into an adult worm over a period of six to twelve months. The small adult male then migrates to the subcutaneous tissue to mate with a large adult female. The adult female usually produces 1,000 to 3,000 microfilariae per day. The eggs mature to the first stage of the microfilariae and are released into the subcutaneous tissue. The microfilariae are then taken up by a female black fly during its "blood meal," mature over a one to three week period, and the O.volvulus life cycle begins again. The life span of the microfilariae is usually one to two years and the life span of the adult worm can be up to fifteen years. [1]

[1]
Ecology of Onchocerca volvulus:

O. volvulus cannot survive in the outside environment; therefore it constantly remains within a host, whether it be the black fly or a human. This parasite causes no harm to the intermediate host and only causes harm to its primary host after the parasite's death. Upon dying the parasite causes inflammation in various areas of the human body, producing nodules that protrude from the skin. This inflammatory response also causes damage to the optical nerves, causing blindness, which is the origin of the disease's name. As previously stated, there is no preventative vaccine or cure for the disease caused by this parasite, but medicine can be taken to temporarily alleviate the pain. [2]

An example of Onchcerca volvulus tranmission and relation to slavery:

O. volvulus is transmitted from human to human through the bites of black flies. Although the majority of the infections still occur in Western and Central Africa, the parasite and the debilitating disease it causes has migrated to other countries, such as those located in South and Central America. This migration is thought to be the result of the slave trade from Africa to these countries in South and Central America. [3] Other diseases that came over with slavery killed many slaves before landing in the New World, reducing the spread and effects of those diseases;however, the disease caused by the aforementioned parasite is not fatal so it was successfully transferred to inhabitants of the New World, causing this debilitating disease to spread to those who forced the Africans into slavery. So, while this parasite is certainly not the cause of the slave trade from Africa, it could be seen as a form of unintentional retaliation from those forced into slavery, and an example of how a small parasite can somewhat alter society and history.

References:

[1]http://en.wikipedia.org/wiki/Onchocerca_volvulus

[2]http://www.science.smith.edu/departments/Biology/SWILLIAM/fgn/pnb/oncvol.html

[3]http://www.suite101.com/content/what-is-river-blindness-a24974

[4]http://www.plosntds.org/article/info%3Adoi%2F10.1371%Fjournal.pntd.0000800


1 comment:

  1. macam mana rumus membendung ejakulasi dini?

    kamu mampu mengahdiri dokter guna berkonsultasi. Dokter bakal merekomendasikan sesi penyuluhan yg menyeret-nyeret psikoterapi. demikian lagi dgn formula berkomunikasi dgn pasangan menyangkut disfungsi seksual. terkecuali pengarahan, pengobatan yang lain serta dapat menyeret-nyeret alat tabiat, anestesi topikal yg( diberikan serta-merta buat kulit), dan sekian banyak remedi. Berikut ini sekian banyak penjelasannya:

    1. proses perilaku
    Seperti yg telah dijelaskan di atas, ejakulasi dini mampu berjalan dikarenakan kamu merasa terpojok. daya upaya perilaku sanggup dibilang tak runyam, kamu bisa jadi dapat direkomendasikan guna masturbasi seputar tunggal, atau dua jam sebelum lakukan senggama. tabiat ini ditujukan buat membimbing ejakulasi dini selagi kamu bersambung seksual. rahasia yang lain yg sepertinya direkomendasikan yaitu menghindari senggama selagi sekian banyak kala buat konsentrasi buat kategori permainan/rangsangan seksual saja, maka tekanan yg menyulut pendapat dekat pikiran kamu bisa dihilangkan.

    BACA berulang: Berapa Kali Masturbasi yg Dianggap sedang Normal?

    2. Latihan basic panggul
    tak cuma wanita yg mampu melaksanakan senam Kegel, cowok pula mampu melakukannya. Senam Kegel mematok otot-otot basic panggul. Ejakulasi dini mampu disebabkan bersama lemahnya otot basic panggul maka kemampuan pada mengganjal ejakulasi tengah 5 memindahkan. Latihan basic panggul dgn senam Kegel sanggup membenarkan otot-otot ini.

    trick melaksanakan senam Kegel:

    - dapatkan otot yg sah. Caranya kamu dapat cobalah aktivitas mengganjal ajaran kencing, atau kencangkan otot disaat kamu mengganjal buang udara. apabila kamu telah meraih otot yg sahih, kamu dapat lakukan kegiatan ini kapan saja. Pastikan perihal ini tak menciptakan kamu jadi mengganjal urin, atau menyangga buang cuaca, lantaran dampaknya tak apik terhadap kesegaran. melakukan kegiatan tertera kala tak mau buang air mungil atau buang angin.
    - sejak mulai laksanakan usaha latihan. kamu mampu mengganjal otot basic panggul sewaktu tiga detik, dulu lemaskan buat tiga detik seterusnya. waktu kamu merasakan otot panggul telah sejak mulai menguat, kamu dapat melakukannya sambil bersila, berdiri, atau berjalan
    - Latih konsentrasi kamu. siap sedia terhadap tak latihan melenturkan otot perut, paha, atau pantat. konsentrasi saja terhadap mengencangkan otot panggul. selagi latihan, sebaiknya kamu bernapas leluasa saja, tak butuh menyangga napas Anda
    - Ulangi latihan ini. supaya akhirnya maksimal laksanakan tiga kali pada sehari. kalau, kamu telah bisa melakukannya sekian banyak kali, targetkan 10 kali klise dekat sehari

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